Has anyone seen this happen as in the attached screenshot?
During normal operation, many times the 'content' of the layer manager will simply fail to appear, and it will show through to the image behind. When moving the layer manager, it shows a static image of what was there before the manager was called.
I can click in the middle area, and it will show the highlighted area of the cell I select, and any text contained. Though no images will show as in the case of the frozen/hidden/plot toggles.
The only solution is to restart Autocad and it's just a big PITA. Another user in the office has asked me about this, so I've excluded that it's anything specific to Autocad hating me, personally, as I assumed before.