'Tis what I thought.
Yes, there are several xrefs, typically.
Initially, it took about 8 minutes to just boot AutoCAD with our default template.
All menus, toolbars, etc. were extremely slow.
After pathing all the support files, etc. locally, it works as normal. I'm not sure they'll like that, but if that's what it takes to be productive.....?
Inventor may be another story all together.