Its pretty strange going through the first time, but yes, you use the Sytem ADI Printer to address the networked version of it. You need the plotter to be attached to a network print server instead of a local version of the driver, otherwise you will be manually correcting the users fallible changes to the driver instead of issues as a central process in a production environment.
Of course DWG to PDF is a stand alone driver too, but using the System Printer was my most stable direction in the Add Plotter Wizard. I setup an individual dwg & dwt file for each paper size layout on the network to import for every publish and every layout template. I had to retrain everyone to use imported page setups and purge the old page setups. It led to a much more predictable plotting environment even when they used a .Plot. If you retain old page setups, you run into dead time with every file looking around the network for the printer when opening the file. If the page setup isn't found locally it looks on the network. Use a default like DWG to PDF which can be much simpler to control especially in a multi office environment. You can save that as the local driver to the network used by every workstation and office because hardware can vary too easily.
Initial setup was pain staking but once its done, it is reuseable and stable as well as predictable. Make sure you are using the networked version of the plotter driver in the setup. Local versions of the driver will just drive you nuts.
You will have to make sure you save all of the preferences in the page setups, driver, and PMP files. Network those settings for every workstation in a networked profile. It sounds more complicated than it is. Get people to adopt work spaces and save them locally. The profile can involve some preferences like right click options, MBUTTONPAN, etc... but over all drivers and fonts are much more easily addressed in a network location using mapped drives in Windows.
If this is your responsibility to control and maintain for everyone, ask for two PC's to use and two separate Active directory logins for Windows. One as an Admin, and one as a regular user. Your run all of the tests as an Admin. Then test again as a regular user to understand the specifics of your plotting environment. Network permissions can cause trouble as much as the driver setup. Once you get it stable it works from version 2007 through 2013. Minor adjustments are either ctb or stb controlled base dupon your layer standards and standard drawing templates used.