The A/E/C CADD Standard that the DOD uses specifies that title blocks should go in model space, in their own drawing. All model information goes in one or more "model" drawings. Each plotted page has a separate "plot" drawing - no multiple layouts allowed. The various model drawings are then XREFd together, along with the title block, in the "plot" drawings.
This method works, and does not have any issues with scaling, since that is all controlled in the "plot" drawing. Your title block is in a seperate drawing from your model, so it is isolated from your model, which is also good. It all works, it just creates a proliferation of files - what could be done in one drawing file now takes three, all XREFd together.
The only work we do that follows this standard is for the US Air Force Academy, and they actually ignore this part of the standard. They keep the "model" and "plot" drawing concept, and still do the 1 printed page = 1 "plot" drawing, but they have us put the title block in paper space in the "plot" drawing.