This might suggest that you start a new file, and save it, then insert the problematic file into the new one, and explode it on the way through the door.
Then Save the file.
Then use design center to go rescue your layout tabs from the possessed file that will not save.
Drag those babies in and Save the file.
Now either keep new file name or....Test doing a save as over the bad one, and see if it then will save, close, open and save before getting rid of the Life Pod file.