As the subject says, does anyone know if it's possible to detect if a drawing is being opened by sheet set manager for purposes of plotting?
I think the best way to figure out what to do is to ask:
What are you ultimately trying to achieve?
If we know the end goal, perhaps we can help you find a solution, because as far as I am aware (and I am fairly familiar with sheet set manager these days), there is no easy way to determine this, but there might be other ways around whatever issue you are having. One approach you could take is to add a custom property and make your lisp routine set it to a certain value, then plot, then reset it back again and then you just check the custom property.