Well, you obviously need to have a ViewModel that implements INotifyPropertyChanged interface and expose a property that has the value of "LUNITS". Since you want to use a COMBOBOX, that means you expect the LUNIT value to be changed in a list of pre-determined value. So, the ViewModel may also provide a list of LUNIT values (type of "Double") as the ComboBox's "ItemsSource", or you can hard-code the ComboBox's item list in XAML, if the pre-determined list does not change at all.
Then, in your ViewModel, you may need to handle AutoCAD's SystemVariableChanged event to monitor if LUNIT is changed or not, and when LUNIT changes, the ViewModel's property that is bound to the ComboBox's SelectedValue/Item would set and trigger's OnPropertyChange in the ViewModel, so that the UI is notified and the ComboBox gets updated automatically.