Looks like for DGN files and DWF files, there is an XData item if the item is not to be loaded. Don't know about the PDF, as I couldn't figure out how to load one.
Get the ' namedobjdict '.
Then for DGN files, look for ' ACAD_DGNDEFINITIONS '
for DWG files, look for ' ACAD_DWFDEFINITIONS '
within the NOD.
Then each item, code 350, will be the definition.
If there is an XData entry of
(-3 ((ACAD (1000 . "NOLOAD"))))
then it will not load, otherwise it is loaded.