There should not be any issues, but one can never be entirely certain.
The last update (AFAIK) that had any impact on Autocad was the one that restricted access to help files. Microsoft did this sometime last year, because the Microsoft HTML Help system uses IE, and is therefore susceptible to any attack that can hit IE. Microsoft's way around it was to change system defaults so that .chm files cannot be read over a network. You probably only noticed this if you've added a company-specific MyHelp to Autocad, and you placed the MyHelp.chm file on a network server. There is a workaround for it listed on Microsoft's web page.