Command line for the most part, a few toolbars and pull-downs . . .
How are you managing that in Civil 3D? I had to leave many of my command line tools behind when I jumped to Civil 3D . . . I only use a select few anymore and only when I am doing strictly AutoCAD functions. I have to hold my nose and use the pulldowns and toolbars more than I care to, but I am growing quite fond of the right click and double click context menus. I guess most of the work now happens in a tool palette if that is where you classify Toolspace.
I used to use quite a few toolbars, but I've been using a lot more pull-downs since the switch to C3D. I still use a lot of command-line stuff, including accelerator keys and temporary keyboard overrides. I actually LIKED some of the DI stuff (not all of it, but some of it), and was using it a lot in Land Desktop, but it causes havok in C3D, so now DI stays off at all times. C3D even has problems with running OSNAPS, so those are usually disabled now, too.
And actually, in C3D, an awful lot of what I do involves going to Prospector... So I guess it's now become a mix of command-line, Prospector window, and pull-downs for almost everything...
We still use Tool Palettes for a few things. I had really started getting used to the incredibly-convenient Hatch Tools, and am sorely disappointed that they don't work (at least in any usable way) in C3D... Autodesk giveth, and Autodesk taketh away...