Some time back, I added the following to my ACADDOC.LSP file:
(defun c:pp ()
(command "-purge" "r" "" "n")
(princ)
)
Now I just type "PP" to get rid of the REGAPPS.
Land Desktop and Civil Design seem to create a lot of the things. I regularly purge upwards of 10,000 of them, and it can make a significant difference to file size. They always come back, but I tend to purge them before eTransmitting or archiving a project, if I think of it.