Both computers are nearly identical. The only thing that jumps to mind is maybe something is geeked out with the "bad computer's" AutoCAD profile and/or Windows profile.
On my computer, the drawing in question opens up like it should. On the other computer it seems to hang while opening one of the temp files - you know, down at the bottom where it says 'Opening C:\Temp\file.ac$'.
The temp folder has been cleaned, the drawings have been purged/audited. Not sure where else to look besides the profiles.
Any ideas, suggestions?