I use the Enterprise.cui and I make a VPN version of the entire package local for laptops specifically.
Laptops don't do enough high volume production to need updates as often.
Most are used to just view/demo files for clients.
Changing the configuration is usually as simple as a find/replace with a text editor on the .arg, .cui, .mnl, (.lsp routines requiring an actual drive location)
The biggest trick I had was making sure I built the VPN's after the main app always.
Would be more difficult to use find/replace when everything points to C: instead of only half the paths like the networked version.
Likely one of the best ways to maintain a stable environment to troubleshoot against.
Use a few default workspaces in the enterprise cui and a central profile.
Point the profile with a desktop icon.
The user messes up functionality, rename the profile in Options and restart AutoCAD from the desktop profile pointed icon.
One of the easiest fixes I have had for maintaining predictable troubleshooting.