I vary the ltscale within a drawing depending on what the line represents, and to distinguish between different objects.
Are you talking about LTSCALE, or the object linetype scale?
If you are saying you regularly use a different object linetype scale for each object, then I have to say that I absolutely abhor it when people do that. It's almost as bad as when people use object properties to set color, linetype, and/or plot style, instead of doing things ByLayer. I admit that I will change the object linetype scale occasionally, but not as a general practice.
It is far, far better to create linetypes that display correctly when the object linetype scale is 1, and LTSCALE is equal to DIMSCALE (which means they will also display correctly when LTSCALE=1 and PSLTSCALE=1).