Yes my profile is loaded, it's part of my desktop shortcut: (profile is the "C3D_Imperial")
"C:\Program Files\Autodesk\AutoCAD 2016\acad.exe" /ld "C:\Program Files\Autodesk\AutoCAD 2016\\AecBase.dbx" /p "<<C3D_Imperial>>" /product "C3D" /nologo
I also have a LISP routine that loads a few things and includes the following line to include my workspace:
(setvar "wscurrent" "Civil 3D")